Determining the surface concentration and diffusivity of cell-membrane-bound molecules is central to the understanding of numerous important biochemical processes taking place at cell membranes. Here we use the high aspect ratio and lightguiding properties of semiconductor nanowires (NWs) to detect the presence of single freely diffusing proteins bound to a lipid bilayer covering the NW surface.
Damiano Verardo, Björn Agnarsson, Vladimir P. Zhdanov, Fredrik Höök, and Heiner Linke
Recent publications
Fluorescence Signal Enhancement in Antibody Microarrays Using Lightguiding Nanowires
Fluorescence-based detection assays play an essential role in the life sciences and medicine. To offer [...]
Aligned Bio får 23 miljoner och tunga delägare
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“A” Round Funding Announcement
Aligned Bio, a single molecule detection company, announced an oversubscribed A round investment of 23MSEK [...]
Aligned Bio’s Nanowire Biosensor Platform – Seed Funding Announcement
Aligned Bio, an advanced nanowire biosensor platform provider, announced a 5M+ SEK seed round led [...]
Single-Molecule Detection with Lightguiding Nanowires: Determination of Protein Concentration and Diffusivity in Supported Lipid Bilayers
Determining the surface concentration and diffusivity of cell-membrane-bound molecules is central to the understanding of [...]
Nanowires for Biosensing: Lightguiding of Fluorescence as a Function of Diameter and Wavelength
Semiconductor nanowires can act as nanoscaled optical fibers, enabling them to guide and concentrate light [...]